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The gene silencing of ACSL4 in primary microglial cells has been reported to impede ferroptosis of microglia induced by HIV-1 Tat protein, with an effect comparable to that of the administration of Fer-1 or DFO ( Figure 3 )

Unconventional secretion of annexins and galectins

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Health Topics 2011c

Lower concentrations of GABA have been observed in major depression and post-traumatic stress disorder in the brain, and a region of the brain known as the insular cortex that is associated with emotional response.* Lower insula levels of GABA are associated with a significantly higher trait and state anxiety.* GABA, as an inhibitory neurotransmitter, is one of the mediators responsible for reducing the response to fear or anxiety-provoking stimuli.*